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Oxycodone is a semi-synthetic opioid with agonistic properties on mu, kappa, and delta-type opioid receptors, with the strongest affinity for mu-type receptors. Upon binding to these G-protein–coupled receptors, it stimulates the exchange of guanosine diphosphate (GDP) on the G-alpha sub unit for guanosine triphosphate (GTP), inhibiting adenylate cyclase and decreasing intracellular cyclic adenosine monophosphate (cAMP). This signal cascade leads to a consequent inhibition of the nociceptive neurotransmitters acetylcholine, dopamine, gamma-aminobutyric acid (GABA), noradrenaline, and substance P and the hormones glucagon, insulin, somatostatin, and vasopressin. To get cheap Oxycodone online USA to your door steps, you are well here.
As with other opioids, oxycodone causes hyperpolarization and reduced excitability of neurons in the central nervous system (CNS). This generalized CNS depression results from the agonistic effect on kappa-type receptors, leading to N-type voltage-gated calcium channel closure. In contrast, stimulation of the mu and delta-type receptors opens calcium-dependent inward-rectifying potassium channels.
Immediate-release tablets: These are available in 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg, while capsules are 5 mg strength. The oral solution is available in 5 mg/5 mL strength, and the oral concentrate is in 100 mg/5 mL strength. Manufacturers discontinued the 160 mg dose in May 2001 due to the high misuse potential.
Extended-release tablets: These are available in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg strengths. Tablets are not intended to be broken, chewed, crushed, or dissolved in liquid.
Abuse-deterrent tablets: These are available in 9 mg, 13.5 mg, 18 mg, 27 mg, and 36 mg strengths.
Pediatric dosing
Acute pain: Initial recommended doses of oxycodone are 0.05 to 0.15 mg/kg every 4 to 6 hours as needed for adequate analgesia of acute pain. Further dosing should be titrated upwards for pain control, with attention and monitoring for potential adverse effects.
Chronic pain: It is recommended to titrate dosage slowly upwards, starting at the lowest possible dose for analgesia for patients with chronic pain. However, the medication should be taken at regularly scheduled intervals for chronic pain management to prevent the reoccurrence of pain instead of treating the pain after it has started.
Management of Overdose
The antidote for overdose is an opioid antagonist medication. Clinicians should administer IV naloxone for Oxycodone overdose
Side Effects
See also Warning section.
Possible Side Effects
You may experience symptoms such as nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. These side effects often diminish over time as your body adjusts. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.
To help manage constipation, aim for a high-fiber diet, keep well-hydrated, and stay active. A laxative might also be helpful—ask your pharmacist which one suits you best.
To minimize feelings of dizziness or lightheadedness, rise slowly when moving from sitting or lying down.
Your medication has been prescribed because your doctor believes its benefits outweigh potential risks. Most users do not experience serious adverse reactions.
If you notice serious side effects—including interrupted breathing during sleep, mood or mental changes (like agitation, confusion, or hallucinations), severe abdominal pain, difficulty urinating, or signs of adrenal gland issues (such as loss of appetite, unusual fatigue, or weight loss)—inform your doctor immediately.
Warnings & Risks of Oxycodone
Oxycodone carries a risk of abuse, addiction, overdose, and possibly fatal respiratory depression. To reduce these risks, your doctor will prescribe the lowest effective dose for the shortest duration possible
Consider having naloxone available to reverse an opioid overdose, and make sure your family or others in your household recognize overdose symptoms and how to respond
The risk of dangerous respiratory side effects is greatest when you start this medication, after dose increases, or if taken incorrectly. Combining oxycodone with alcohol or other sedatives can significantly raise the risk of serious, even fatal, side effects
Some medications also affect how quickly oxycodone is processed by your body, which may alter its effects. Always check for possible drug interactions with your doctor or pharmacist
If any of these serious symptoms occur—such as very slow or shallow breathing, extreme drowsiness, fainting, or difficulty waking—seek emergency medical attention immediately
Keep oxycodone secured at all times to prevent theft or misuse. If someone accidentally takes it, get medical help right away.
Pregnancy and Newborn Considerations
Women of childbearing age should discuss the risks and benefits of oxycodone with their doctor. Inform your provider if you are pregnant or planning to become pregnant .
During early pregnancy (especially the first two months), oxycodone may slightly increase the risk of birth defects. Extensive use or high doses near the due date may harm the unborn baby. Use only the minimum effective dose for the shortest duration.
Babies exposed to oxycodone over an extended period before birth may suffer severe withdrawal symptoms. Contact your doctor right away if your newborn shows signs like inconsolable crying, shallow breathing, irritability, trembling, vomiting, diarrhea, feeding problems, or poor weight gain
Emergency and Allergic Reactions
If you experience extremely serious symptoms—such as fainting, seizures, slow or shallow breathing, or difficulty waking—seek medical help immediately
Although rare, serious allergic reactions may occur. If you notice rash, itching, swelling (especially around the face/tongue/throat), severe dizziness, or breathing trouble, seek emergency assistance right away
This summary does not list all possible side effects. For any other unusual symptoms, consult your doctor or pharmacist
Overdose Instructions
If someone overdoses—with symptoms like unconsciousness or breathing trouble—administer naloxone if available and call emergency services (e.g., 911) immediately. This is a medical emergency
If the person is alert and symptom-free, call your local poison control center—for example, 1‑800‑222‑1222 in the U.S. or 1‑844‑764‑7669 in Canada
Overdose may present with slow or shallow breathing, slow heartbeat, coma, cold clammy skin, limpness, or inability to wake up
Important Additional Notes
Do not share this medication—it's illegal and unsafe
Use this medicine only for the prescribed condition. Do not repurpose it for other ailments unless directed by your doctor.
If You Miss a Dose
If you're on a regular dosing schedule and you miss one, take it as soon as possible—unless the next dose is imminent. In that case, skip the missed dose and proceed with your normal schedule. Do not double dose.
Storage & Disposal
Store oxycodone at room temperature, shielded from light and moisture—not in the bathroom. Keep it safely out of reach of children and pets.
When no longer needed or expired, dispose of the medication properly. If no drug take-back program is available, flushing may be advised—consult your pharmacist or local disposal guidelines.
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